Quantifying structural changes in the ageing brain from magnetic resonance imaging
نویسنده
چکیده
.............................................................................................................................. iii Publications arising from this thesis ....................................................................... vi Section 1: Introduction and methods ....................................................................... 7 Chapter 1. General Introduction ............................................................................... 7 1.1 Ageing and society ............................................................................................................ 7 1.2 Healthy ageing and ageing research ........................................................................... 8 1.3 Magnetic Resonance Imaging and its role in studying ageing processes ....... 9 1.4 The ageing brain .............................................................................................................. 12 1.5 Research into ageing ...................................................................................................... 14 1.6 Assessing the ageing brain on MRI ............................................................................ 17 Chapter 2. General methods ................................................................................... 19 2.1 LBC1936 cohort ................................................................................................................ 19 2.2 Subjects .............................................................................................................................. 20 2.3 Cognitive testing ............................................................................................................... 21 2.4 Brain MRI acquisition protocol ..................................................................................... 23 2.5 Pre-processing steps and Image analysis ............................................................... 24 2.6 Normal-appearing white matter (NAWM) and cerebrospinal fluid (CSF). ...... 25 2.7 Grey matter volume ......................................................................................................... 27 2.8 Whole brain volume ......................................................................................................... 32 2.9 Ventricular volume ........................................................................................................... 33 Section 2: Systematic reviews ................................................................................. 38 Chapter 3. Systematic review of automated hippocampal segmentation methods in healthy elderly population .................................... 39 3.
منابع مشابه
Brain Structural Changes Caused by Autism Spectrum Disorder Based on Volumetric Analysis of Magnetic Resonance Images: A Review Study
Background and purpose: Autism spectrum disorder (ASD) is a psychiatric disorder which occurs in early years of life and causes various individual and social problems. Early detection of autism would help in taking necessary precautions and preventing its adverse side effects. Methods & Materials: In this paper, we reviewed the articles that have investigated brain structural changes caused by...
متن کاملPseudo-CT Generation from Magnetic Resonance Imaging by fuzzy look up table algorithm
Introduction: Despite growing interest in the use of magnetic resonance imaging (MRI) in the external radiotherapy design process (RT), Computer Tomography (CT) remains a gold standard and is regarded as a basic imaging modality in radiotherapy. MRI shows the high contrast in soft tissues without any radiation exposure to patients. As a result, MRI is used in functional tissue ...
متن کاملCLINICAL CORRELATIONS BETWEEN AUDITORY BRAIN STEM RESPONSE AND MAGNETIC RESONANCE IMAGING IN PATIENTS WITH DEFINITE MULTIPLE SCLEROSIS
In an attempt to assess objectively the integrity of the auditory pathways in 30 patients with definite multiple sclerosis (MS), an audiometric evaluation was performed and auditory brainstem responses (ABRs) were obtained. Stressing the auditory system by increasing the stimulation rate showed some enhancement in the identification of MS. 24 (RO%) patients had an abnormal ABR along with c...
متن کاملDetection of Alzheimer\'s disease based on magnetic resonance imaging of the brain using support vector machine model
Background: Alzheimer's disease (AD) is the most common disorder of dementia, which has not been cured after its occurrence. AD progresses indiscernible, first destroy the structure of the brain and subsequently becomes clinically evident. Therefore, the timely and correct diagnosis of these structural changes in the brain is very important and it can prevent the disease or stop its progress. N...
متن کاملSegmentation of Magnetic Resonance Brain Imaging Based on Graph Theory
Introduction: Segmentation of brain images especially from magnetic resonance imaging (MRI) is an essential requirement in medical imaging since the tissues, edges, and boundaries between them are ambiguous and difficult to detect, due to the proximity of the brightness levels of the images. Material and Methods: In this paper, the graph-base...
متن کامل